Alginate degrading enzymes: an updated comprehensive review of the structure, catalytic mechanism, modification method and applications of alginate lyases

Alginate, a kind of linear acidic polysaccharide, consists ?-L-guluronate (G) and ?-D-mannuronate (M). Both alginate its degradation products (alginate oligosaccharides) possess abundant biological activities such as antioxidant activity, antitumor antimicrobial activity. Therefore, oligosaccharides have great value in food, pharmaceutical, agricultural fields. Alginate lyase can degrade into via the ?-elimination reaction. It plays an important role marine carbon recycling deep utilization brown algae. Elucidating structural features improve our knowledge catalytic mechanisms. With development analysis techniques, increasing numbers lyases been characterized at level. Hence, it is essential helpful to summarize discuss up-to-date findings. In this review, we summarized progress on mechanisms lyases. Furthermore, molecular modification strategies applications also discussed. This comprehensive information should be expand